Renin, aka angiotensinogenase, is a 340 amino acid enzyme (which also acts as a hormone). Its molecular weight is 340 kDa.
It is secreted by the juxtaglomerular cells (JG) cells of the juxtaglomerular apparatus in response to 3 stimuli:
- Hypotension (baroreceptors)
- Decreased delivery of sodium or chloride to the distal tubule (macula densa)
- β1 adrenergic stimulation (sympathetic nervous system)
Renin uses its endopeptidase activity to cleave angiotensinogen, to yield angiotensin I. This is the first step in the activation of the renin-angiotensin-aldosterone system (RAAS)
References
https://en.wikipedia.org/wiki/Renin
https://link.springer.com/article/10.1007/BF00584260 - β1 adrenergic stimulation
Congratulations @ikservices! You have completed the following achievement on the Hive blockchain And have been rewarded with New badge(s)
<table><tr><td><img src="https://images.hive.blog/60x70/http://hivebuzz.me/@ikservices/upvoted.png?202211281644" /><td>You received more than 300 upvotes.<br />Your next target is to reach 400 upvotes. <p dir="auto"><sub><em>You can view your badges on <a href="https://hivebuzz.me/@ikservices" target="_blank" rel="noreferrer noopener" title="This link will take you away from hive.blog" class="external_link">your board and compare yourself to others in the <a href="https://hivebuzz.me/ranking" target="_blank" rel="noreferrer noopener" title="This link will take you away from hive.blog" class="external_link">Ranking<br /> <sub><em>If you no longer want to receive notifications, reply to this comment with the word <code>STOP <p dir="auto"><strong><span>Check out the last post from <a href="/@hivebuzz">@hivebuzz: <table><tr><td><a href="/hive-102201/@hivebuzz/wc2022-recap-day9"><img src="https://images.hive.blog/64x128/https://i.imgur.com/uNPMgnd.png" /><td><a href="/hive-102201/@hivebuzz/wc2022-recap-day9">HiveBuzz World Cup Contest - Recap of Day 9<tr><td><a href="/hive-122221/@hivebuzz/pud-202212"><img src="https://images.hive.blog/64x128/https://i.imgur.com/805FIIt.jpg" /><td><a href="/hive-122221/@hivebuzz/pud-202212">Hive Power Up Day - December 1st 2022<tr><td><a href="/hive-102201/@hivebuzz/wc2022-ranking"><img src="https://images.hive.blog/64x128/https://i.imgur.com/8kplXrX.png" /><td><a href="/hive-102201/@hivebuzz/wc2022-ranking">HiveBuzz World Cup Contest - Check your ranking <h6>Support the HiveBuzz project. <a href="https://hivesigner.com/sign/update_proposal_votes?proposal_ids=%5B%22199%22%5D&approve=true" target="_blank" rel="noreferrer noopener" title="This link will take you away from hive.blog" class="external_link">Vote for <a href="https://peakd.com/me/proposals/199" target="_blank" rel="noreferrer noopener" title="This link will take you away from hive.blog" class="external_link">our proposal!